World Stroke Organization #MondayTips
Every Monday, WSA Social Media Leader Rodrigo Guerrero publishes a #MondayTip on the WSA WorldStrokeEd Twitter account, covering a specific stroke related topic. You can find a compilation of our #MondayTips here!
📰May #Newsletter
What did you miss in May—and what’s next in #StrokeEducation?
👩💻Webinars
🌍ESOC 2026 highlights
📋Paper of the Month #OCEANICStroke
🎙️New vodcast series on Factor XI/XIa inhibition
🌦️Climate change & #stroke
🧠Latest #MondayTips
Here!👉https://world-stroke-academy.org/news/may-newsletter-3/
#MondayTip
#Thrombophilia & Young #cryptogenic stroke Abnormalities are common early, but high-risk findings are rare
🤫SECRETO: 37.1%👉any abnormality; only 5.2% were high-risk
🧠Screen smarter: prior VTE, inactivity, low HDL-C or anemia may guide testing
https://doi.org/10.1161/strokeaha.125.053251
#MondayTIP
#PerihematomalEdema
🩸After ICH, #PHE edema growth matters
📈In an IPD meta-analysis, PHE growth on CT at 24–72h was independently linked to death/dependence at 90 days
🎯Repeat CT may aid risk stratification and trial design
https://doi.org/10.1161/strokeaha.125.053991
#MondayTip
#Early ticagrelor+aspirin after IV thrombolysis may improve 90-day excellent recovery in selected moderate AIS (NIHSS 4–10)
🚶♀️mRS 0–1 68.7% vs 62.0%
🩸sICH was rare, but CIs were wide.
☝️Defined phenotype, not broad adoption yet
#TAPIS
🔗https://doi.org/10.1016/s0140-6736(26)00757-9
May #PaperofTheMonth: 𝐎𝐂𝐄𝐀𝐍𝐈𝐂-𝐒𝐓𝐑𝐎𝐊𝐄: 𝐅𝐚𝐜𝐭𝐨𝐫 𝐗𝐈𝐚 𝐈𝐧𝐡𝐢𝐛𝐢𝐭𝐢𝐨𝐧 𝐒𝐭𝐞𝐩𝐬 𝐢𝐧𝐭𝐨 𝐒𝐞𝐜𝐨𝐧𝐝𝐚𝐫𝐲 𝐒𝐭𝐫𝐨𝐤𝐞 𝐏𝐫𝐞𝐯𝐞𝐧𝐭𝐢𝐨𝐧
🤓Commentary
🔽#MondayTip
🎧4 expert interview episodes
Access it: https://www.world-stroke-academy.org/news/the-paper-of-the-month-may-4/
#StrokeEducation
#MondayTip 🧠
🌍From #ESOC2026 to practice: stroke care is moving across the whole pathway: BP control, imaging, EVT selection, adjunctive therapies, cooling, mobility & recovery.
☝️Better outcomes will come from better systems, sharper selection, and evidence-based details
#MondayTip
#TRIDENT
💊One pill could change post-ICH care.
🧠Low-dose triple antihypertensive therapy ↓ recurrent stroke by 39% and improved BP control vs standard care
☝️Simpler regimens may beat therapeutic inertia
🔗https://doi.org/10.1056/nejmoa2515043
#MondayTip
#Tenecteplase may help—even when the artery stays closed.
In #TRACE3 (4.5–24h window), pts without recanalization still had better outcomes (42% vs 30%). Strongest effect in NIHSS ≥10.
👉 Think beyond large vessel reopening
https://doi.org/10.1186/s12916-026-04877-x
#MondayTip
Can we prevent stroke without increasing bleeding?
Factor XIa inhibition #asundexian :
🔹⬇️recurrent stroke (HR 0.74)
🔸with no ⬆️major bleeding in OCEANIC-STROKE.
A potential shift in secondary prevention. 🧠⚖️
🔗 https://www.nejm.org/doi/full/10.1056/NEJMoa2513880
#MondayTip
#GFAP
📈Rises early in intracerebral hemorrhage (2–6h)🩸, but later in ischemic stroke (peak days 2–5)
💡Promising for early differentiation & triage
☝️but not ready as a standalone test
https://doi.org/10.3390/jcm14217748
#MondayTip
#Collaterals
Collateral status are relevant in stroke
🧠 Good collaterals + recanalization → strong outcomes
⚠️ Poor collaterals → limited benefit, even if opened
CTA isn’t just diagnostic—it’s decision-making
https://doi.org/10.3174/ajnr.a3817
#MondayTip
Cancer-related stroke ≠ routine ESUS
~50% of strokes in active cancer are cryptogenic, but many are cancer-driven hypercoagulable events
🔁14–29% recur at 1 year
⚖️Anticoag vs aspirin? Still equipoise
🧠Classify. Risk-stratify. Individualize
https://doi.org/10.1161/str.0000000000000517
#MondayTip
Hypoperfusion Intensity Ratio
#HIR may be the most practical collateral biomarker in AIS
⬆️High HIR (>0.4) → rapid core growth, ↑ hemorrhage risk, worse mRS.
⬇️Low HIR → robust collaterals & better EVT outcomes.
https://doi.org/10.3174/ajnr.A8557
Missed what happened in February at @WorldStrokeEd? 👀
Catch up with our monthly newsletter!
🎓 Upcoming & past webinars
🎙️ New podcast episodes
📊 Fresh infographics
💡 Latest #MondayTips by @interneurona
🤓 Read it here:
https://www.world-stroke-academy.org/news/february-newsletter-3/
#StrokeEducation #StrokeCare
#MondayTip
Not all “seizures” are epilepsy.
🧠 #LimbShakingTIA = hypoperfusion from carotid disease
📌 Triggered by standing/exertion
📉 EEG often normal
⚠️ Treat flow, not firing
https://doi.org/10.1136/pn-2025-004976
#MondayTip
New AHA dyslipidemia guides emphasizes earlier &➕ intensive LDL-C⬇️, often requiring non-statin therapy
PCSK9 options:
🧬Inclisiran (siRNA):↓PCSK9 production, dosing every 6m
💉Alirocumab/Evolocumab:✋circulating PCSK9
Both ↓LDL~50–60%, including in stroke patients
📰May #Newsletter
What did you miss in May—and what’s next in #StrokeEducation?
👩💻Webinars
🌍ESOC 2026 highlights
📋Paper of the Month #OCEANICStroke
🎙️New vodcast series on Factor XI/XIa inhibition
🌦️Climate change & #stroke
🧠Latest #MondayTips
Here!👉https://world-stroke-academy.org/news/may-newsletter-3/
🧠What does the landmark #OCEANICSTROKE trial mean for clinical practice?
Join our expert webinar on secondary stroke prevention, Factor XI/XIa inhibition, and future anticoagulation strategies.
📅Monday 15 June, 16:00 CEST
Register: https://us02web.zoom.us/webinar/register/WN_1zkjXKuETeSwFD093LUu9Q#/registration
#StrokeEducation
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🔴Live now with Prof. @mike_sharma2 presenting his talk on 'Factor XIa Inhibition with Asundexian in Acute Non-Cardioembolic Stroke or High-Risk Transient Ischemic Attack: Primary Results of the OCEANIC-STROKE Trial'
#MondayTip
#Thrombophilia & Young #cryptogenic stroke Abnormalities are common early, but high-risk findings are rare
🤫SECRETO: 37.1%👉any abnormality; only 5.2% were high-risk
🧠Screen smarter: prior VTE, inactivity, low HDL-C or anemia may guide testing
https://doi.org/10.1161/strokeaha.125.053251
